Penelitian

Sebagai wujud turut serta dalam Tri-dharma Perguruan Tinggi, Unit Pelayanan Onkologi Radiasi RSUP Nasional Dr. Cipto Mangunkusumo dan Prodi Onkologi Radiasi FKUI terlibat dalam berbagai kegiatan penelitian baik nasional dan internasional. Berbagai capaian yang diperoleh adalah penghargaan baik di tingkat nasional maupun internasional dan publikasi di jurnal internasional terakreditasi SCOPUS. Berikut juga disertakan daftar publikasi, penelitian kolaborasi internasional yang sedang berjalan dan penelitian hibah.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Publikasi internasional terakreditasi SCOPUS

 

2017

 

  1. Radiation or chemoradiation: initial utility study of selected therapy for local advanced stadium cervical cancer

(Prof. Dr. dr. Soehartati Gondhowiardjo, Sp.Rad(K)Onk.Rad)

https://iopscience.iop.org/article/10.1088/1742-6596/884/1/012120/meta

  1. An Agent-Based Simulation Approach for Government Intervention in Reducing High-Risk HPV

(Prof. Dr. dr. Soehartati Gondhowiardjo, Sp.Rad(K)Onk.Rad)

https://link.springer.com/chapter/10.1007/978-981-10-3662-0_3

  1. Status of Radiotherapy around the World: Southeast Asia. Chapter 25.4

(Prof. Dr. dr. Soehartati Gondhowiardjo, Sp.Rad(K)Onk.Rad; dr. Gregorius Ben Prajogi, Sp.Onk.Rad, M.Pd)

https://www-pub.iaea.org/MTCD/Publications/PDF/P1638_web.pdf

  1. Multicentre dose audit for clinical trials of radiation therapy in Asia

(dr. Nana Supriana, Sp,Rad(K)Onk.Rad)

https://www.ncbi.nlm.nih.gov/pubmed/27864507

  1. Need for Competency-Based Radiation Oncology Education in Developing Countries

(dr. Gregorius Ben Prajogi, Sp.Onk.Rad, M.Pd)

https://m.scirp.org/papers/73531

  1. DNA double-strand break repair pathway regulatesPD-L1 expression in cancer cells

(dr. Tiara Bunga Mayang Pemata, MARS, Ph.D; dr. Endang Nuryadi, Sp.Onk.Rad, Ph.D)

https://www.nature.com/articles/s41467-017-01883-9.pdf

  1. Molecular Mechanism of PD-L1 Upregulation in Cancer Cells after X-Ray Irradiation

(dr. Tiara Bunga Mayang Pemata, MARS, Ph.D; dr. Endang Nuryadi, Sp.Onk.Rad, Ph.D)

https://www.redjournal.org/article/S0360-3016(17)31427-X/abstract

  1. Homogeneous and inhomogeneous material effect in gamma index evaluation of IMRT technique based on fan beam and Cone Beam CT patient images

(Wahyu Edy Wibowo, M.Si, FM, Sp.RT)

https://iopscience.iop.org/article/10.1088/1742-6596/851/1/012021

  1. Dosimetric characteristics of gafchromic EBT3 film on small field electron beam

(Wahyu Edy Wibowo, M.Si, FM, Sp.RT; Nurrudin Nasution, S.Si)

https://iopscience.iop.org/article/10.1088/1742-6596/851/1/012023/meta

  1. Motion effects in stereotactic body radiotherapy (SBRT) dosimetry of bone metastases: case study using homogeneous and inhomogeneous CIRS phantoms

(Wahyu Edy Wibowo, M.Si, FM, Sp.RT)

https://iopscience.iop.org/article/10.1088/1742-6596/851/1/012027

  1. Dosimetric evaluation of IMRT plan for homogenous and inhomogeneous medium using AAPM TG-119 protocol

(Wahyu Edy Wibowo, M.Si, FM, Sp.RT)

https://iopscience.iop.org/article/10.1088/1742-6596/851/1/012022/meta

  1. Conventional and conformal technique of external beam radiotherapy in locally advanced cervical cancer : Dose distribution, tumor response, and side effects

(Prof. Dr. H.M. Djakaria, Sp.Rad(K)Onk.Rad)

https://iopscience.iop.org/article/10.1088/1742-6596/884/1/012122

  1. Stadium I B – II A cervical cancer patient’s survival rate after receiving definitive radiation and radical operation therapy along with analysis of factors affecting the patient’s survival rate

(Dr. dr. Irwan Ramli, Sp.Rad(K)Onk.Rad)

https://iopscience.iop.org/article/10.1088/1742-6596/884/1/012121

  1. The characteristics of dose at mass interface on lung cancer Stereotactic Body Radiotherapy (SBRT) Simulation

(Wahyu Edy Wibowo, M.Si, FM, Sp.RT)

https://iopscience.iop.org/article/10.1088/1742-6596/851/1/012028

  1. Implementation of small field radiotherapy dosimetry for spinal metastase case

(Wahyu Edy Wibowo, M.Si, FM, Sp.RT)

https://aip.scitation.org/doi/pdf/10.1063/1.4991172

  1. The detector characteristics for output factor measurement of small field electron beams

(Wahyu Edy Wibowo, M.Si, FM, Sp.RT)

https://aip.scitation.org/doi/pdf/10.1063/1.4991176

2018

 

  1. Geometric accuracy on verification of stereotactic radiotherapy with theuse of a double mask versus the Leksell G frame

(Prof. Dr. dr. Soehartati Gondhowiardjo, Sp.Rad(K)Onk.Rad)

https://iopscience.iop.org/article/10.1088/1742-6596/1073/4/042029/pdf

  1. Nasopharyngeal cancer : towards the ever elusive goal of standardization

(dr. Gregorius Ben Prajogi, Sp.Onk.Rad, M.Pd)

http://anpc.amegroups.com/article/view/4319

  1. Von willebrand factor plasma level and bleeding scale score before and after radiation therapy for cancer-related bleeding

(Dr. dr. Sri Mutya Sekarutami, Sp.Rad(K)Onk.Rad)

https://iopscience.iop.org/article/10.1088/1742-6596/1073/4/042030

  1. Inter-assay precision of clonogenic assays for radiosensitivity in cancer cell line A549

(dr. Endang Nuryadi, Sp.Onk.Rad, Ph.D; dr. Tiara Bunga Mayang Pemata, MARS, Ph.D)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862609/

  1. Mutational analysis of uterine cervical cancer that survived multiple rounds of radiotherapy

(dr. Endang Nuryadi, Sp.Onk.Rad, Ph.D; dr. Tiara Bunga Mayang Pemata, MARS, Ph.D)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135691/

  1. Analysis of programmed death-ligand 1 expression in primary normal human dermal fibroblasts after DNA damage

(dr. Tiara Bunga Mayang Pemata, MARS, Ph.D)

https://www.sciencedirect.com/science/article/abs/pii/S0198885918301587

 

2019

 

  1. Diagnostic Approach for Thyroid Nodules

(Prof. Dr. dr. Soehartati Gondhowiardjo, Sp.Rad(K)Onk.Rad; dr. Henry Kodrat, Sp.Onk.Rad)

http://www.actamedindones.org/index.php/ijim/article/view/1051

  1. Current Immune-Related Molecular Approach in Combating Nasopharyngeal Cancer

(Prof. Dr. dr. Soehartati Gondhowiardjo, Sp.Rad(K)Onk.Rad; dr. Henry Kodrat, Sp.Onk.Rad)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785271/

  1. Practical Guidelines Management of Graves Ophthalmopathy

(Prof. Dr. dr. Soehartati Gondhowiardjo, Sp.Rad(K)Onk.Rad; dr. Henry Kodrat, Sp.Onk.Rad)

https://europepmc.org/article/med/32041923

  1. PD-L1 profile of nasopharyngeal cancer patients in Indonesia

(dr. Handoko, Sp.Onk.Rad; Prof. Dr. dr. Soehartati Gondhowiardjo, Sp.Rad(K)Onk.Rad; dr. Henry Kodrat, Sp.Onk.Rad; dr. Tiara Bunga Mayang Permata, MARS, Ph.D)

https://www.journals.elsevier.com/annals-of-oncology

  1. Protein Intake, Prognostic Nutritional Index and Quality of Life in Head and Neck Cancer Patients Undergoing Radiotherapy

(Dr. dr. Sri Mutya Sekarutami, Sp.Rad(K)Onk.Rad)

https://inabj.org/index.php/ibj/article/view/570

  1. Role of Cancer Stem Cell, Apoptotic Factor, DNA Repair, and Telomerase Toward Radiation Therapy Response in Stage IIIB Cervical Cancer

(Dr. dr. Sri Mutya Sekarutami, Sp.Rad(K)Onk.Rad)

https://www.ncbi.nlm.nih.gov/pubmed/31110630

  1. Base excision repair regulates PD-L1 expression in cancer cells

(Prof. Dr. dr. Soehartati Gondhowiardjo, Sp.Rad(K)Onk.Rad; dr. Tiara Bunga Mayang Permata, MARS, Ph.D)

https://www.nature.com/articles/s41388-019-0733-6

  1. Global Collaborations for Cervical Cancer: Can the East-West Alliance Facilitate Treatment for all?

(Prof. Dr. dr. Soehartati Gondhowiardjo, Sp.Rad(K)Onk.Rad)

https://www.ncbi.nlm.nih.gov/pubmed/31229379

  1. Multi-institutional Observational Study of Prophylactic Extended-Field Concurrent Chemoradiation Therapy Using Weekly Cisplatin for Patients With Pelvic Node-Positive Cervical Cancer in East and Southeast Asia

(dr. Nana Supriana, Sp.Rad(K)Onk.Rad)

https://www.ncbi.nlm.nih.gov/pubmed/31125594

  1. Validation of recursive partitioning analysis, graded prognostic assessment and basic score for brain metastases as prognostic indices among patients with brain metastases treated with radiotherapy in Indonesia

(Prof. Dr. dr. Soehartati Gondhowiardjo, Sp.Rad(K)Onk.Rad; Dr. dr. Irwan Ramli, Sp.Rad(K)Onk.Rad)

https://www.cambridge.org/core/journals/journal-of-radiotherapy-in-practice/article/validation-of-recursive-partitioning-analysis-graded-prognostic-assessment-and-basic-score-for-brain-metastases-as-prognostic-indices-among-patients-with-brain-metastases-treated-with-radiotherapy-in-indonesia/9C9916DAADE55577A0E7321F2131AA0B

  1. Improving access to radiation therapy in Indonesia

(Prof. Dr. dr. Soehartati Gondhowiardjo, Sp.Rad(K)Onk.Rad; Dr. dr. Sri Mutya Sekarutami, Sp.Rad(K)Onk.Rad; dr. Angela Giselvania, Sp.Onk.Rad)

https://appliedradiationoncology.com/articles/improving-access-to-radiation-therapy-in-indonesia

  1. The Global Radiation Oncology Workforce In 2030: Estimating Physician Training Needs And Proposing Solutions To Scale Up Capacity In LMICS

(dr. Gregorius Ben Prajogi, Sp.Onk.Rad, M.Pd)

https://appliedradiationoncology.com/articles/the-global-radiation-oncology-workforce-in-2030-estimating-physician-training-needs-and-proposing-solutions-to-scale-up-capacity-in-low-and-middle-income-countries

  1. Developing National Cancer Guideline: A Step Toward Standardized Multidisciplinary Management in Indonesia

(Prof. Dr. dr. Soehartati Gondhowiardjo, Sp.Rad(K)Onk.Rad; dr. Angela Giselvania, Sp.Onk.Rad; Dr. dr. Arie Munandar, Sp.Onk.Rad)

https://ascopubs.org/doi/abs/10.1200/jgo.18.71400

  1. The Role of Multisectoral Collaboration in Indonesia

(dr. Angela Giselvania, Sp.Onk.Rad; Prof. Dr. dr. Soehartati Gondhowiardjo, Sp.Rad(K)Onk.Rad)

https://ascopubs.org/doi/abs/10.1200/jgo.18.71100

  1. Deep learning-assisted literature mining for in vitro radiosensitivity data

(dr. Endang Nuryadi, Sp.Onk.Rad, Ph.D; dr. Tiara Bunga Mayang Pemata, MARS, Ph.D)

https://www.sciencedirect.com/science/article/pii/S0167814019329822

  1. Robustness of Clonogenic Assays as a Biomarker for Cancer Cell Radiosensitivity

(dr. Endang Nuryadi, Sp.Onk.Rad, Ph.D)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747107/

  1. Clinical Sequencing Analysis of the Mutation Profiles Associated with Extreme Radioresistance

(dr. Endang Nuryadi, Sp.Onk.Rad, Ph.D)

https://www.redjournal.org/article/S0360-3016(19)31046-6/fulltext

  1. Inter-Study Precision of Cancer Cell Radiosensitivity AsAssessed By Colony Formation Assay

(dr. Endang Nuryadi, Sp.Onk.Rad, Ph.D)

https://www.redjournal.org/article/S0360-3016(19)31813-9/fulltext

  1. The future of radiotherapy and immunotherapy concomitantly in cancer management

(Dr. dr. Sri Mutya Sekarutami, Sp.Rad(K)Onk.Rad)

http://mji.ui.ac.id/journal/index.php/mji/article/view/3211

  1. Dosimetry analysis on IMRT, VMAT, and HT technique in  hippocampal  sparing  whole-brain radiotherapy

(Prof. Dr. dr. Soehartati Gondhowiardjo, Sp.Rad(K)Onk.Rad; Dr. dr. Arie Munandar, Sp.Onk.Rad; Wahyu Edy Wibowo, M.Si, FM, Sp.RT; Dr. dr. Irwan Ramli, Sp.Rad(K)Onk.Rad; Dr. dr. Sri Mutya Sekarutami, Sp.Rad(K)Onk.Rad)

https://www.oncologyradiotherapy.com/articles/dosimetry-analysis-on-imrt-vmat-and-ht-technique-in-hippocampal-sparing-wholebrain-radiotherapy.pdf

  1. The impact of pitch and modulation factor to tomotherapy treatment plan optimization for motion target

(Wahyu Edy Wibowo, M.Si, FM, Sp.RT)

https://iopscience.iop.org/article/10.1088/1742-6596/1248/1/012055

  1. Evaluation Of MLC errors of LINAC based on log file

(Wahyu Edy Wibowo, M.Si, FM, Sp.RT)

https://iopscience.iop.org/article/10.1088/1742-6596/1248/1/012057

  1. Determination of composite field correction factor kpcsr,msr for tomotherapy

(Wahyu Edy Wibowo, M.Si, FM, Sp.RT)

https://iopscience.iop.org/article/10.1088/1742-6596/1248/1/012058

  1. 2D dose reconstruction of IMRT patient-specific QA based on log file

(Wahyu Edy Wibowo, M.Si, FM, Sp.RT)

https://www.sciencedirect.com/science/article/pii/S0969806X19305638

 

2020

 

  1. Kinetics of Prostate-Specific Antigen after Carbon Ion Radiotherapy for Prostate Cancer

(Prof. Dr. dr. Soehartati Gondhowiardjo, Sp.Rad(K)Onk.Rad)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139713/

  1. Tumor microenvironment predicts local tumor extensiveness in PD-L1 positive nasopharyngeal cancer

(Prof. Dr. dr. Soehartati Gondhowiardjo, Sp.Rad(K)Onk.Rad; dr. Handoko, Sp.Onk.Rad, dr. Henry Kodrat, Sp.Onk.Rad; dr, Tiara Bunga Mayang Permata, MARS, Ph.D)

https://www.ncbi.nlm.nih.gov/pubmed/32191754

  1. Multifocal recurrence of medulloblastoma: a long follow-up case study

(Prof. Dr. dr. Soehartati Gondhowiardjo, Sp.Rad(K)Onk.Rad)

https://mji.ui.ac.id/journal/index.php/mji/article/view/3480

  1. Survivin and Telomerase as Radiotherapeutic Response Predictors of Subjects with Stage IIIB Cervical Squamous Cell Carcinoma

(Dr. dr. Sri Mutya Sekarutami, Sp.Rad(K)Onk.Rad)

https://inabj.org/index.php/ibj/article/view/813

  1. Survival of nasopharyngeal cancer in national referral hospital of Indonesia: A study on radiotherapy patients

(Dr. dr. Sri Mutya Sekarutami, Sp.Rad(K)Onk.Rad; Prof. Dr. dr. Soehartati Gondhowiardjo, Sp.Rad(K)Onk.Rad)

https://www.ncbi.nlm.nih.gov/pubmed/32305651

  1. Preliminary survey of 3D image-guided brachytherapy for cervical cancer at representative hospitals in Asian countries

(dr. Henry Kodrat, Sp.Onk.Rad)

https://www.ncbi.nlm.nih.gov/pubmed/32367130

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Penelitain kolaborasi internasional

 

Kolaborasi  dengan International Atomic Energy Agency (IAEA)

  1. Optimisation of Radiotherapy Treatment in Paediatric Cancer
  2. Resource-Sparing Curative Treatment for Rectal Cancer
  3. A Randomized Phase III Study of Short Course (One-week) Radiation Therapy versus Standard Course (Three-week) Radiation Therapy in Elderly and/or Frail Patients with Newly Diagnosed Glioblastoma Multiforme
  4. Resource Sparing Curative Radiotherapy for Locally Advance Squamous Cell Cancer of Head and Neck (On going)
  5. Randomized Phase III Clinical Trial of Stereotactic Body Radiation Therapy Versus Transarterial Chemoembolization in Hepatocellular Carcinoma (On going)
  6. A Situation Analysis of National Radiotherapy Resources and Patterns of care for Patients with Nasopharyngeal Carcinoma in Low-Middle Income Countries: Can Enhancing the Quality of Radiotherapy Planning Improve Outcomes (Pattern of Care Study of NPC Management in Indonesia) (On going)
  7. Efficacy of Spatially-Fractionated Radiation Therapy (SFRT) in palliative treatment of lung and cervical cancer patients (Masih Pengajuan Kontrak)

Kolaborasi  dengan Forum for Nuclear Cooperation in Asia (FNCA)

  1. 3D-Image-guided brachytheraphy for Locally Advanced Cervical Cancer (Cervix-V).

 

 

 

 

 

 

 

 

 

 

 

 

Penelitian yang mendapat hibah

Berikut adalah penelitian yang mendapat hibah;

  1. Hubungan HPV dengan Hipoksia terhadap Respon Radiasi pada Karsinoma Sel Skuamosa Rongga Mulut dan Orofaring
  2. PD-L1, EBV, dan Tumor microenvironment pada Kanker Nasofaring (PITTA UI 2019)
  3. Hubungan Ekspresi PD-L1 Intratumoral Pre Radiasi terhadap Respons Radiasi pada Pasien Kanker Serviks Stadium Lanjut Lokal (PITTA UI 2019)
  4. Microsatellite Instability Status in Nasopharyngeal Cancer (PUTI Q1 2020)
  5. Microsatellite Instability Status in Cervical Cancer (PUTI Q1 2020)
  6. Regulatory T cells in Nasopharyngeal Cancer Microenvironment (PUTI Q2 2020)
  7. Regulatory T Cells in Cervical Cancer Microenvironment (PUTI Q2 2020)
  8. EBV Viral Protein in Nasopharyngeal Cancer (PUTI Q3 2020)
  9. HPV protein in cervical cancer (PUTI Q3 2020)
  10. Correlation between Sleep Patterns and Habits with Melatonin Levels in Patients with Cervical Cancer (PUTI Q3 2020)
  11. Large Animals Induced Diethylnitrosamine and Phenobarbital as Hepatocellular Carcinoma Model for Spatially Fractionated GRID Radiotherapy Technique (PUTI Doktor 2020)
  12. Relationship Between Post-Radiation Tumor Responses to Post-Radiation Vitamin D Levels and Pre-Radiation Intratumoral Vitamin D Receptor Expressions in Nasopharyngeal Cancer (PUTI Saintekes 2020)
  13. Prevalence of Vitamin D Deficiency in Cancer Patients and Its Influence on Carcinogenesis (PUTI Saintekes 2020)
  14. Molecular and Clinical Prognostic Factors in Glioma (PUTI Saintekes 2020)
  15. Molecular Prognostic Factors in Brain Tumor (PUTI Saintekes 2020)
  16. Efek Radiosensitizer Ekstrak Eucheuma cottonii pada Human Cancer Cell Line HeLa dan DU145 (PUTI Saintekes 2020)
  17. Potensi Gallic Acid sebagai Radiosensitizer pada Human Cancer Cell Line HeLa dan DU145 (PUTI Saintekes 2020)
  18. In Vitro Study of Annona muricata L. Leaves Extract in Enhancing Radiation Efficacy in Prostate Adenocarcinoma Cell Line (DU 145 Cells) and Cervical Adenocarcinoma (HeLa Cells) (PUTI Saintekes 2020)
  19. Desain dan Rancang Bangun Penunjang Penyinaran Stereotaktik Radioterapi dengan Masker Termoplastik dan Polyurethan Head Rest (Hibah operasional RSCM)